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PubMed · 15387638

Diterpenoids from Isodon melissoides.

Ai-Hua Zhao·Quan-Bin Han·Rong-Tao Li·Sheng-Hong Li·Chen Qing·Yan-Li Zhang·Qin-Shi Zhao·Fu-Sheng Wang·Han-Dong Sun
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Abstract

Nine new diterpenoids, melissoidesins M-U (1-9), along with five known analogues, melissoidesin F (10), xindongnin B (11), melissoidesin G (12), melissoidesin E (13), and dawoensin A (14), were isolated from the aerial parts of Isodon melissoides. The structures of new compounds were elucidated by analysis of spectral evidence including extensive 2D NMR data. Compounds 2, 3, 7, 11, 12, and 14 showed cytotoxicity against the human tumor BGC-823 cell line with IC(50) values less than 10 microg/mL, respectively.

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Antineoplastic Agents, PhytogenicChinaDiterpenesDrug Screening Assays, AntitumorHumansInhibitory Concentration 50IsodonMolecular StructureNuclear Magnetic Resonance, BiomolecularPlants, MedicinalStereoisomerismTumor Cells, CulturedJournal Article

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Ai-Hua Zhao, Quan-Bin Han, Rong-Tao Li, Sheng-Hong Li, Chen Qing, Yan-Li Zhang, Qin-Shi Zhao, Fu-Sheng Wang, Han-Dong Sun. 2004. Diterpenoids from Isodon melissoides.. https://doi.org/10.1021/np030418l

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