Solvable senescence model with positive mutations.

J B Coe; Y Mao; M E Cates

doi:10.1103/physreve.70.021907

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Solvable senescence model with positive mutations.

J B Coe·Y Mao·M E Cates

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Abstract

We build upon our previous analytical results for the Penna model of senescence to include positive mutations. We investigate whether a small but nonzero positive mutation rate gives qualitatively different results to the traditional Penna model in which no positive mutations are considered. We find that the high-lifespan tail of the distribution is radically changed in structure, but that there is not much effect on the bulk of the population. The mortality plateau that we found previously for a stochastic generalization of the Penna model is stable to a small positive mutation rate.

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Animals Birth Rate Cellular Senescence Life Expectancy Models, Genetic Models, Statistical Models, Theoretical Mutation Time Factors Journal Article

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J B Coe, Y Mao, M E Cates. 2004-08-17. Solvable senescence model with positive mutations.. https://doi.org/10.1103/physreve.70.021907

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