Hope for a broken heart?

Patrick Most; Carmen Eicher; Mirko Völkers; Sven T Pleger; Hugo A Katus

doi:10.1016/j.tibtech.2004.08.004

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PubMed · 15450736

Hope for a broken heart?

Patrick Most·Carmen Eicher·Mirko Völkers·Sven T Pleger·Hugo A Katus

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Abstract

Heart failure affects 23 million people worldwide and results from cardiac dysfunction characterized by decreased responsiveness to beta-adrenergic stimulation. A recent publication by W.J. Koch and colleagues highlights evidence for targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer to improve contractile function and beta-adrenergic responsiveness in failing human myocardium. This proof-of-concept study has great importance for future heart failure therapy because it provides evidence for the therapeutic effectiveness of betaARK1 inhibition in failing human myocardium.

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Adenoviridae Animals Cyclic AMP-Dependent Protein Kinases Enzyme Inhibitors Genetic Therapy Heart Failure Humans Mice Myocardium Myocytes, Cardiac Peptides Transgenes beta-Adrenergic Receptor Kinases Journal Article

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Patrick Most, Carmen Eicher, Mirko Völkers, Sven T Pleger, Hugo A Katus. 2004. Hope for a broken heart?. https://doi.org/10.1016/j.tibtech.2004.08.004

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