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PubMed · 15459660

Checking on DNA damage in S phase.

Jiri Bartek·Claudia Lukas·Jiri Lukas
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Abstract

The precise replication of the genome and the continuous surveillance of its integrity are essential for survival and the avoidance of various diseases. Cells respond to DNA damage by activating a complex network of the so-called checkpoint pathways to delay their cell-cycle progression and repair the defects. In this review we integrate findings on the emerging mechanisms of activation, the signalling pathways and the spatio-temporal organization of the intra-S-phase DNA-damage checkpoint and its impact on the cell-cycle machinery, and discuss its biological significance.

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AnimalsAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCell LineCheckpoint Kinase 1Checkpoint Kinase 2DNA DamageDNA-Binding ProteinsEnzyme ActivationGenes, cdcHumansProtein KinasesProtein Serine-Threonine KinasesS PhaseSignal TransductionTime FactorsTumor Suppressor Proteinscdc25 PhosphatasesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Jiri Bartek, Claudia Lukas, Jiri Lukas. 2004. Checking on DNA damage in S phase.. https://doi.org/10.1038/nrm1493

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