Airway epithelial cell-pathogen interactions.

Alessandra Bragonzi; Elena Copreni; Sophie de Bentzmann; Martina Ulrich; Massimo Conese

doi:10.1016/j.jcf.2004.05.041

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Airway epithelial cell-pathogen interactions.

Alessandra Bragonzi·Elena Copreni·Sophie de Bentzmann·Martina Ulrich·Massimo Conese

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Abstract

Cystic fibrosis (CF) airway becomes colonized with only a limited number of bacterial pathogens. It is of paramount importance to establish in vitro and in vivo models to better understand bacterial-host interactions under CF-like conditions. In this article, in vitro methods suitable to study Pseudomonas aeruginosa (Pa) and Staphylococcus aureus (Sa) adherence to and uptake by airway epithelial cells are described. Acute and chronic respiratory infection models, which have been used in CF transgenic mice and mimic human CF lung pathology, are also taken into consideration.

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Animals Apoptosis Bacterial Adhesion Bacterial Infections Cell Culture Techniques Cystic Fibrosis DNA Fragmentation Endocytosis Epithelial Cells Humans Mice Mice, Transgenic Models, Biological Pseudomonas aeruginosa Respiratory Mucosa Respiratory Tract Infections Staphylococcus aureus Journal Article Research Support, Non-U.S. Gov't

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Alessandra Bragonzi, Elena Copreni, Sophie de Bentzmann, Martina Ulrich, Massimo Conese. 2004. Airway epithelial cell-pathogen interactions.. https://doi.org/10.1016/j.jcf.2004.05.041

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