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[Mice lacking PACAP: a mini-review focussing on brain function].

Norihito Shintani
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Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal peptide (VIP)/ secretin/ glucagon superfamily and functions as a hormone, neurohormone, and neurotransmitter in the central nervous system as well as in several peripheral tissues. Recently, several groups including ours have independently produced lines of mice lacking PACAP (PACAP(-/-)). These mutant mice have not only led to a better understanding of the physiologic roles of endogenous PACAP, but have also revealed some unexpected roles of PACAP. In this paper, phenotypic changes in several brain functions in PACAP(-/-) mice, including light-induced phase-resetting of the circadian activity rhythm, hippocampal long-term potentiation, and psychomotor behaviors, are reviewed based on the results obtained in our laboratory.

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AnimalsBehavior, AnimalBrainCircadian RhythmGene DeletionHippocampusLong-Term PotentiationMiceMice, Mutant StrainsNeuronal PlasticityNeuropeptidesPituitary Adenylate Cyclase-Activating PolypeptidePsychomotor PerformanceEnglish AbstractJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Norihito Shintani. 2004. [Mice lacking PACAP: a mini-review focussing on brain function].. https://doi.org/10.1248/yakushi.124.667

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