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PubMed · 15467444

Regulation in S phase by E2F.

Arthur B Pardee·Chiang J Li·G Prem Veer Reddy
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Abstract

The DNA synthetic S phase of the unperturbed cell cycle is a closed system, as compared to regulation of G(1) by external growth factors. The E2F family provides internal control in S phase by transcribing genes required for deoxynucleotide triphosphate (dNTP) and DNA synthesis. Furthermore, over expression of E2F-1 activates programmed cell death (apoptosis), a safeguarding signal of aberrant growth of cells that have become carcinogenic. Mechanisms for control of E2F-1 are thus essential. The hypothesis is proposed that deoxythymidine triphosphate (dTTP) allosterically feedback controls E2F-1 to regulate both DNA synthesis and apoptosis. This may act either upon production of E2F-1 or its degradation.

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Allosteric RegulationAnimalsApoptosisCell Cycle ProteinsDNAE2F Transcription FactorsFeedback, PhysiologicalHumansS PhaseThymine NucleotidesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Arthur B Pardee, Chiang J Li, G Prem Veer Reddy. 2004-09-04. Regulation in S phase by E2F.. https://pubmed.ncbi.nlm.nih.gov/15467444/

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