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PubMed · 15469344

Caged trans-4-hydroxy-2-nonenal.

Robert G Brinson·Paul B Jones
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Abstract

[reaction: see text] A caged 4-hydroxy-2-nonenal (4-HNE) has been prepared and its photochemistry investigated. Upon photolysis, 1 releases 4-HNE in up to 100% yield. From these photolyses, 4-HNE could be isolated in up to 91% yield. 4-HNE is produced under either aerobic or anaerobic conditions. The caging strategy does not require prior preparation of 4-HNE and, therefore, represents a three-step synthetic route to the bioactive enal in 48% overall yield.

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AldehydesPhotochemistrySpectrophotometry, UltravioletJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

Robert G Brinson, Paul B Jones. 2004-10-14. Caged trans-4-hydroxy-2-nonenal.. https://doi.org/10.1021/ol048478l

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