PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 15478578

Current topics in bone metastases.

View original source ↗Export metadata ↓

Abstract

Patients with cancer who have bone metastases may live for several years following diagnosis. However, skeletal disease significantly impacts quality of life, causing bone pain, pathologic fractures, spinal cord compression, and hypercalcemia. This program covered the challenges of treatment, new standards of care, advances in nursing, responsibilities in supportive care, and current trials investigating options for treatment-induced bone loss. The program ended with a call to nurses to become more active as patient advocates.

Explore related subjects

Bone NeoplasmsFractures, SpontaneousHumansHypercalcemiaNurse's RoleOncology NursingPainPatient AdvocacyQuality of LifeSpinal Cord CompressionJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

2004. Current topics in bone metastases.. https://pubmed.ncbi.nlm.nih.gov/15478578/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2008

Hematometrocolpos in an adolescent female treated for pelvic Ewing sarcoma.

Radiation therapy is often used to achieve local control of pelvic Ewing sarcoma in children. The effects of radiation on the female reproductive tract have been well documented in adults with gynecological malignancies, but the long-term consequences of pelvic radiation in pre-pubertal or adolescent girls are not as well described. We report a case of hematometrocolpos developing in an adolescent previously treated with chemotherapy and radiation therapy for pelvic Ewing sarcoma. We describe the clinical presentation, radiographic features, gross pathology, treatment strategies, outcome, as well as putative predisposing factors and preventative interventions.

Bone Neoplasms↗
PubMed2007

Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer.

BACKGROUND: Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4/hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa. METHODS: Immunohistochemistry, in vitro co-culture, cell migration, and attachment assays. RESULTS: hK4 was localized to tumor cells and osteoblasts in bone metastases. KLK4/hK4 increased in LNCaP and PC3 cells co-cultured with SaOs2 cells; SaOs2 KLK4/hK4 was unchanged. Co-culture did not affect cell proliferation but altered alkaline phosphatase activity/mRNA levels in SaOs2 cells. KLK4-transfected PC3 cells had increased migration towards SaOs2 conditioned medium and greater attachment to the bone-matrix proteins, collagens I and IV. CONCLUSIONS: hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in PCa bone metastasis. Whether this observation is unique to bone metastasis or reflects a role for hK4 in PCa metastasis generally is yet to be established.

Bone Neoplasms↗