IL-3 in dendritic cell development and function: a comparison with GM-CSF and IL-4.

Manfred B Lutz

doi:10.1016/j.imbio.2004.03.001

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IL-3 in dendritic cell development and function: a comparison with GM-CSF and IL-4.

Manfred B Lutz

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Abstract

Dendritic cells (DC) develop in vivo from hematopoietic precursor cells. This process can be mimicked in vitro by growth factor stimulation. Among those factors granulocyte-macrophage colony-stimulating factor (GM-CSF) is the best known and most widely used for generation of rodent and human DC of the myeloid lineage. GM-CSF is often combined with interleukin-4 (IL-4) to suppress macrophage (Mph) outgrowth in cultures of human cells, but this does not apply to the mouse, and detailed analyses on the role of IL-4 are rare. Despite evidence for the importance of GM-CSF for DC development derived from in vitro data, GM-CSF-deficient mice are largely normal with respect to their DC populations. This raised the interest in other growth factors for DC. IL-3 can also support DC growth in vitro, but has been neglected for some years. Now it has been revived by a series of publications. In this review, some new features of myeloid DC regarding their early developmental stages, the GM-CSF/IL-4-interplay, and the role of IL-3 are summarized.

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Animals Dendritic Cells Granulocyte-Macrophage Colony-Stimulating Factor Interleukin-3 Interleukin-4 Mice Mice, Inbred BALB C Mice, Inbred C57BL Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

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Manfred B Lutz. 2004. IL-3 in dendritic cell development and function: a comparison with GM-CSF and IL-4.. https://doi.org/10.1016/j.imbio.2004.03.001

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