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PubMed · 15491776

Not all progestins are the same: implications for usage.

Janet P Hapgood·Dominique Koubovec·Ann Louw·Donita Africander
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Abstract

Recent clinical evidence showing unexpected side-effects of progestins used in contraception and hormone replacement therapy has highlighted the importance of choice of synthetic progestin. The molecular mechanisms of action of the relatively nonspecific and most widely used synthetic progestins, medroxyprogesterone acetate and norethisterone, are discussed in the context of this recent clinical evidence. Future directions involving a more mechanism-based approach for improved therapeutics, with greater specificity and fewer side-effects, are discussed.

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Contraceptives, Oral, SyntheticHumansMedroxyprogesteroneNorethindroneProgesterone CongenersStructure-Activity RelationshipJournal ArticleReview

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Janet P Hapgood, Dominique Koubovec, Ann Louw, Donita Africander. 2004. Not all progestins are the same: implications for usage.. https://doi.org/10.1016/j.tips.2004.09.005

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PubMed2006

Mifepristone alters expression of endometrial steroid receptors and their cofactors in new users of medroxyprogesterone acetate.

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Contraceptives, Oral, Synthetic↗
PubMed2006

Metabolic and clinical effects of progestogens.

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