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PubMed · 15500120

[Refractory nephrotic syndrome].

Takao Saito
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Abstract

In Japan, refractory nephrotic syndrome is defined as a pathological condition resistant to the treatment using corticosteroids and other immunosuppressive for 6 months or more. The Research Group on Progressive Renal Disease sponsored by the Ministry of Health Labor and Welfare of Japan reported that 10 to 12% of the cases with idiopathic nephrotic syndrome were classified into this type and that the most common cause in adults is idiopathic membranous nephropathy (40%) and the second is focal segmental glomerulosclerosis (20%). In these conditions, less than 10% progressed to end stage renal disease (ESRD) when urine protein decreased under 1 g/day by the treatment. Persistent proteinuria is not only a marker of irreversible glomerular lesions but also a risk factor for tubulointerstitial lesions, which plays a significant role in progression into ESRD.

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Angiotensin-Converting Enzyme InhibitorsAnticoagulantsBiomarkersBlood Component RemovalDrug ResistanceGlomerulonephritis, MembranousGlomerulosclerosis, Focal SegmentalGlucocorticoidsHumansImmunosuppressive AgentsKidney Failure, ChronicLipoproteins, LDLNephritis, InterstitialNephrotic SyndromePrednisolonePrognosisProteinuriaRisk FactorsEnglish AbstractJournal ArticleReview

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Takao Saito. 2004. [Refractory nephrotic syndrome].. https://pubmed.ncbi.nlm.nih.gov/15500120/

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