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PubMed · 15502365

Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes.

Hajime Motoyoshi·Masato Horigome·Ken Ishigami·Tatsuhiko Yoshida·Sueharu Horinouchi·Minoru Yoshida·Hidenori Watanabe·Takeshi Kitahara
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Abstract

The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate the binding proteins.

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BiotinBiotinylationCell CyclePyransSpiro CompoundsStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov't

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Hajime Motoyoshi, Masato Horigome, Ken Ishigami, Tatsuhiko Yoshida, Sueharu Horinouchi, Minoru Yoshida, Hidenori Watanabe, Takeshi Kitahara. 2004. Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes.. https://doi.org/10.1271/bbb.68.2178

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