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Antigenic differences between apo-B in native and circulating modified low-density lipoproteins.

I V Suprun·A A Mel'nichenko·E V Yanushevskaya·T N Vlasik·I A Sobenin·O M Panasenko·A N Orekhov
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Abstract

The state of apo-B in native and circulating modified low-density lipoproteins was studied by solid-phase enzyme immunoassay. We studied the interaction of these particles with monoclonal antibodies to apo-B of low-density lipoproteins. Native and circulating modified low-density lipoproteins had different affinity for the studied antigens. Our results illustrate conformational changes in apo-B of circulating modified low-density lipoproteins compared to native low-density lipoproteins. These changes probably contribute to increased accumulation of particles in vascular cells and their transformation into foam cells giving way to atherosclerotic vascular lesions.

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Antibodies, MonoclonalApolipoproteins BArteriosclerosisHumansImmunoassayLipoproteins, LDLProtein ConformationComparative StudyJournal Article

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I V Suprun, A A Mel'nichenko, E V Yanushevskaya, T N Vlasik, I A Sobenin, O M Panasenko, A N Orekhov. 2004. Antigenic differences between apo-B in native and circulating modified low-density lipoproteins.. https://doi.org/10.1023/b%3Abebm.0000046934.76907.9d

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