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Roles for bone-marrow-derived cells in beta-cell maintenance.

Jeffery S Tessem·James DeGregori
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Abstract

With more than 177 million people suffering from diabetes worldwide, and the number expected to double by 2030, finding new ways to treat this disease is a high priority. Intensive effort is being directed towards developing mechanisms for increasing beta-cell expansion as a diabetic therapeutic. Recent studies, in which adult bone marrow has been used to induce beta-cell expansion in mice, have shown both exciting and controversial results. In these reports, marrow-derived cells can contribute towards beta-cell maintenance both by promoting endogenous beta-cell expansion and possibly by transdifferentiation into beta-cells. These studies reveal mechanisms for potential therapeutic intervention.

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AnimalsBone Marrow CellsBone Marrow TransplantationCell DifferentiationDiabetes MellitusHumansIslets of LangerhansMicePancreasJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Jeffery S Tessem, James DeGregori. 2004. Roles for bone-marrow-derived cells in beta-cell maintenance.. https://doi.org/10.1016/j.molmed.2004.09.002

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