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CD4+ Tregs and immune control.

Zoltán Fehérvari·Shimon Sakaguchi
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Abstract

Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25+CD4+ Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance of immunological tolerance and to impinge on a host of clinically important areas from cancer to infectious diseases. The identification of specific molecular markers in both human and murine immune systems has enabled the unprecedented investigation of these cells and should prove key to ultimately unlocking their clinical potential.

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AnimalsCD4-Positive T-LymphocytesForkhead Transcription FactorsHumansImmune SystemImmune ToleranceLigandsMiceModels, BiologicalPhenotypeReceptors, Interleukin-2Repressor ProteinsT-Lymphocytes, RegulatoryThymus GlandJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Zoltán Fehérvari, Shimon Sakaguchi. 2004. CD4+ Tregs and immune control.. https://doi.org/10.1172/jci23395

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