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Apolipoprotein E phenotype affects the malondialdehyde-modified LDL concentration and forearm endothelial function in postmenopausal women.

Mikio Tsuda·Mitsuhiro Sanada·Yukihito Higashi·Yoshiko Hara·Ichiro Kodama·Kazuaki Chayama·Masao Yoshizumi·Koso Ohama
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Abstract

OBJECTIVE: We investigated whether the apolipoprotein E (apo E) phenotype affects the serum concentration of malondialdehyde-modified low-density lipoprotein (MDA-LDL) or forearm endothelial function in postmenopausal women. PATIENTS AND MEASUREMENTS: Individuals were divided into three groups according to their apo E phenotype: E2 (E2/2 and E2/3, n = 12); E3 (E3/3, n = 71); and E4 (E3/4 and E4/4, n = 27). The serum concentrations of lipids and MDA-LDL were measured. Forearm blood flow during reactive hyperaemia and after sublingual nitroglycerin administration was measured by strain-gauge plethysmography. RESULTS: The serum concentrations of total and LDL cholesterol were significantly higher in the E4 group than in the E2 group (P < 0.05) or in the E3 group (P < 0.05). The serum apo B concentration was significantly higher in the E4 group than in the E2 group (P < 0.05). The serum concentrations of high density lipoprotein (HDL) cholesterol and nitrite/nitrate were significantly lower in the E4 group than in the E2 group (P < 0.05). Other lipid concentrations did not differ in the three groups. The serum MDA-LDL concentration was highest in the E4 group, and was lowest in the E2 group (E2: 91.1 +/- 6.9 IU/l, E3: 112.3 +/- 5.9 IU/l, E4: 128.8 +/- 9.9 IU/l; P < 0.05). The forearm blood flow response to reactive hyperaemia was lowest in the E4 group, and highest in the E2 group (E2: 52.2 +/- 5.8 ml/min per 100 ml tissue, E3: 40.7 +/- 1.7 ml/min per 100 ml tissue, E4: 33.4 +/- 2.4 ml/min per 100 ml tissue; P < 0.05). The forearm blood flow changes in response to nitroglycerine were similar between all three groups. CONCLUSIONS: The apo E phenotype affects the serum MDA-LDL concentration and forearm endothelial function in postmenopausal women.

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AgedAnalysis of VarianceApolipoproteins BApolipoproteins ECholesterolCholesterol, HDLCholesterol, LDLFemaleForearmHumansHyperemiaIsoelectric FocusingLipoproteins, LDLMiddle AgedNitroglycerinPhenotypePlethysmographyPostmenopauseRegional Blood FlowVasodilator AgentsComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Mikio Tsuda, Mitsuhiro Sanada, Yukihito Higashi, Yoshiko Hara, Ichiro Kodama, Kazuaki Chayama, Masao Yoshizumi, Koso Ohama. 2004. Apolipoprotein E phenotype affects the malondialdehyde-modified LDL concentration and forearm endothelial function in postmenopausal women.. https://doi.org/10.1111/j.1365-2265.2004.02145.x

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