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Myostatin rapid sequence evolution in ruminants predates domestication.

Asa Tellgren·Ann-Charlotte Berglund·Peter Savolainen·Christine M Janis·David A Liberles
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Abstract

Myostatin (GDF-8) is a negative regulator of skeletal muscle development. This gene has previously been implicated in the double muscling phenotype in mice and cattle. A systematic analysis of myostatin sequence evolution in ruminants was performed in a phylogenetic context. The myostatin coding sequence was determined from duiker (Sylvicapra grimmia caffra), eland (Taurotragus derbianus), gaur (Bos gaurus), ibex (Capra ibex), impala (Aepyceros melampus rednilis), pronghorn (Antilocapra americana), and tahr (Hemitragus jemlahicus). Analysis of nonsynonymous to synonymous nucleotide substitution rate ratios (Ka/Ks) indicates that positive selection may have been operating on this gene during the time of divergence of Bovinae and Antilopinae, starting from approximately 23 million years ago, a period that appears to account for most of the sequence difference between myostatin in these groups. These periods of positive selective pressure on myostatin may correlate with changes in skeletal muscle mass during the same period.

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Amino Acid SequenceAnimalsAnimals, DomesticCattleDNADNA PrimersEvolution, MolecularExonsLikelihood FunctionsModels, GeneticMolecular Sequence DataMuscle DevelopmentMuscle, SkeletalMutationMyostatinPhenotypePhylogenyPolymerase Chain ReactionRuminantsSequence Homology, Amino AcidTime FactorsTransforming Growth Factor betaJournal ArticleResearch Support, Non-U.S. Gov't

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Asa Tellgren, Ann-Charlotte Berglund, Peter Savolainen, Christine M Janis, David A Liberles. 2004. Myostatin rapid sequence evolution in ruminants predates domestication.. https://doi.org/10.1016/j.ympev.2004.07.004

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