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Diverse mechanisms regulate stem cell self-renewal.

Anna V Molofsky·Ricardo Pardal·Sean J Morrison
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Abstract

To what extent are the pathways that regulate self-renewal conserved between stem cells at different stages of development and in different tissues? Some pathways play a strikingly conserved role in regulating the self-renewal of diverse stem cells, whereas other pathways are specific to stem cells in certain tissues or at certain stages of development. Recent studies have highlighted differences between the self-renewal of embryonic, fetal and adult stem cells. By understanding these similarities and differences we may come to a molecular understanding of how stem cells replicate themselves and why aspects of this process differ between stem cells.

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AnimalsCell CycleCell LineageCell ProliferationDrosophila ProteinsEmbryo, MammalianHedgehog ProteinsHumansIntercellular Signaling Peptides and ProteinsMembrane ProteinsModels, BiologicalPolycomb Repressive Complex 1Receptors, NotchSignal TransductionStem CellsTime FactorsWnt ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Anna V Molofsky, Ricardo Pardal, Sean J Morrison. 2004. Diverse mechanisms regulate stem cell self-renewal.. https://doi.org/10.1016/j.ceb.2004.09.004

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