Ligand discovery using small molecule microarrays.

Xuezhong G He; Guillermo Gerona-Navarro; Samie R Jaffrey

doi:10.1124/jpet.104.076943

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Ligand discovery using small molecule microarrays.

Xuezhong G He·Guillermo Gerona-Navarro·Samie R Jaffrey

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Abstract

Small molecule microarrays have recently been used to identify ligands for several proteins, and several themes regarding screening strategies and limitations have emerged. In this review, some of the technical issues related to the manufacture and screening of small molecule microarrays, as well as prospects for small molecule microarrays in several areas of drug discovery and chemistry, are discussed.

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Animals Combinatorial Chemistry Techniques Drug Evaluation, Preclinical Humans Ligands Oligonucleotide Array Sequence Analysis Receptors, Cell Surface Journal Article Research Support, Non-U.S. Gov't Review

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Xuezhong G He, Guillermo Gerona-Navarro, Samie R Jaffrey. 2004-11-10. Ligand discovery using small molecule microarrays.. https://doi.org/10.1124/jpet.104.076943

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