Severe acute respiratory syndrome: thin-section computed tomography features, temporal changes, and clinicoradiologic correlation during the convalescent period.

Ka-tak Wong; Gregory E Antonio; David S C Hui; Catherine Ho; Po-nin Chan; Wing-hung Ng; Kwok-kuen Shing; Alan Wu; Nelson Lee; Florence Yap; Gavin M Joynt; Joseph J Y Sung; Anil T Ahuja

doi:10.1097/00004728-200411000-00010

PubMed · 15538152

Severe acute respiratory syndrome: thin-section computed tomography features, temporal changes, and clinicoradiologic correlation during the convalescent period.

Ka-tak Wong·Gregory E Antonio·David S C Hui·Catherine Ho·Po-nin Chan·Wing-hung Ng·Kwok-kuen Shing·Alan Wu·Nelson Lee·Florence Yap·Gavin M Joynt·Joseph J Y Sung·Anil T Ahuja

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Abstract

OBJECTIVE: To evaluate thin-section computed tomography findings of patients with severe acute respiratory syndrome (SARS) in the convalescent period and to correlate the results with clinical parameters and lung function tests. METHODS: Ninety-nine severe acute respiratory syndrome patients with persistent changes on follow-up chest radiography were included. One hundred seventy computed tomography examinations at baseline (n=70), 3 months (n=56), and 6 months (n=44) were retrospectively evaluated to determine the extent of ground-glass opacification, reticulation, and total parenchymal involvement. Patients' demographic information, clinical information during treatment, and results of lung function tests at 3 and 6 months were correlated with computed tomography findings. RESULTS: A significant serial improvement in the extent of overall ground-glass opacification, overall reticulation, and total parenchymal involvement was observed (P <0.01). Advanced age, previous intensive care unit admission, mechanical ventilation, alternative treatment, higher peak lactate dehydrogenase, and peak radiographic involvement during treatment showed a positive correlation with overall reticulation and total parenchymal involvement at 6 months. There was a significant negative correlation between overall reticulation and total parenchymal involvement with diffusion capacity adjusted for hemoglobin at 3 and 6 months (P <0.01). CONCLUSION: Lung changes on thin-section computed tomography of severe acute respiratory syndrome patients improved with time during the convalescent period and showed a significant correlation with advanced age, parameters indicating severe illness, and diffusion capacity adjusted for hemoglobin on follow-up.

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Ka-tak Wong, Gregory E Antonio, David S C Hui, Catherine Ho, Po-nin Chan, Wing-hung Ng, Kwok-kuen Shing, Alan Wu, Nelson Lee, Florence Yap, Gavin M Joynt, Joseph J Y Sung, Anil T Ahuja. Severe acute respiratory syndrome: thin-section computed tomography features, temporal changes, and clinicoradiologic correlation during the convalescent period.. https://doi.org/10.1097/00004728-200411000-00010

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