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Brd4: tethering, segregation and beyond.

Alison A McBride·Maria G McPhillips·Jaquelline G Oliveira
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Abstract

Papillomaviruses segregate their genomes in dividing cells by tethering them to mitotic chromosomes via the viral E2 protein. A recent report has shown that this interaction is mediated by the cellular bromodomain protein Brd4. This discovery provides new insight into the mechanism of viral genome segregation and raises many exciting questions about the regulation and nature of the interaction of this complex with mitotic chromosomes.

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AnimalsChromosome SegregationChromosomesDNA-Binding ProteinsMitosisPapillomaviridaeViral ProteinsVirus ReplicationJournal ArticleReview

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Alison A McBride, Maria G McPhillips, Jaquelline G Oliveira. 2004. Brd4: tethering, segregation and beyond.. https://doi.org/10.1016/j.tim.2004.10.002

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