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PubMed · 15544065

Dissolution test for ivermectin in oral veterinary paste.

M Sznitowska·J Pietkiewicz·M Stokrocka·S Janicki
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Abstract

A dissolution test for oral veterinary pastes with ivermectin using the Ph. Eur. paddle apparatus was developed. Sink conditions were achieved with sodium lauryl sulphate in a concentration of 0.5% as dissolution medium. By means of HPLC fast degradation of ivermectin was observed in HCl 0.1 M solution. Rotation speed of the paddle at 75 rpm was appropriate as demonstrated in a study comparing two different products.

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AnthelminticsChemistry, PharmaceuticalChromatography, High Pressure LiquidEmulsionsHydrogen-Ion ConcentrationIvermectinSodium Dodecyl SulfateSolubilitySurface-Active AgentsJournal Article

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M Sznitowska, J Pietkiewicz, M Stokrocka, S Janicki. 2004. Dissolution test for ivermectin in oral veterinary paste.. https://pubmed.ncbi.nlm.nih.gov/15544065/

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