SRP-mediated protein targeting: structure and function revisited.

Joen Luirink; Irmgard Sinning

doi:10.1016/j.bbamcr.2004.03.013

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SRP-mediated protein targeting: structure and function revisited.

Joen Luirink·Irmgard Sinning

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Abstract

The signal recognition particle (SRP) and its membrane-bound receptor (SR) deliver membrane proteins and secretory proteins to the translocation channel in the plasma membrane (or the endoplasmic reticulum). The general outline of the SRP pathway is conserved in all three kingdoms of life. During the past decade, structure determination together with functional studies has brought our understanding of the SRP-mediated protein transport to an almost molecular level. An impressive amount of new information especially on the prokaryotic SRP is integrated into the current picture of the SRP pathway.

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Animals Bacterial Proteins Gram-Negative Bacteria Membrane Transport Proteins Protein Conformation Protein Sorting Signals Protein Transport Receptors, Cytoplasmic and Nuclear Ribosomes Signal Recognition Particle Journal Article Research Support, Non-U.S. Gov't Review

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Joen Luirink, Irmgard Sinning. 2004-11-11. SRP-mediated protein targeting: structure and function revisited.. https://doi.org/10.1016/j.bbamcr.2004.03.013

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