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Tocopherol long chain fatty alcohols decrease the production of TNF-alpha and NO radicals by activated microglial cells.

Thierry Muller·Luc Grandbarbe·Eleonora Morga·Paul Heuschling·Bang Luu
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Abstract

The synthesis of a series of Tocopherol long chain Fatty Alcohols (TFA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TFA bearing 12 carbon atoms on the side chain (n=12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS)-activated microglia.

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AnimalsCell LineFatty AlcoholsFree RadicalsMiceMicrogliaMolecular StructureNitric OxideStructure-Activity RelationshipTumor Necrosis Factor-alphaalpha-TocopherolJournal ArticleResearch Support, Non-U.S. Gov't

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Thierry Muller, Luc Grandbarbe, Eleonora Morga, Paul Heuschling, Bang Luu. 2004-12-20. Tocopherol long chain fatty alcohols decrease the production of TNF-alpha and NO radicals by activated microglial cells.. https://doi.org/10.1016/j.bmcl.2004.09.078

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