Lipid-based nanotubes as functional architectures with embedded fluorescence and recognition capabilities.

George John; Megan Mason; Pulickel M Ajayan; Jonathan S Dordick

doi:10.1021/ja0446449

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Lipid-based nanotubes as functional architectures with embedded fluorescence and recognition capabilities.

George John·Megan Mason·Pulickel M Ajayan·Jonathan S Dordick

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Abstract

A limited combinatorial strategy was used to synthesize a small library of soft lipid-based materials ranging from structurally unordered fibers to highly uniform nanotubes. The latter nanotubes are comprised of a bilayer structure with interdigitated alkyl chains associated through hydrophobic interactions. These tubes contain accessible 2,6-diaminopyridine linkers that can interact with thymidine and related nucleosides through multipoint hydrogen bonding, thereby quenching the intrinsic fluorescence of the aromatic linker. These results are the first example of a systematic strategy to design functional lipid nanotubes with precise structural and functional features.

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Aminopyridines Combinatorial Chemistry Techniques Cross-Linking Reagents Fatty Acids Lipids Microscopy, Fluorescence Monosaccharides Nanotubes Scattering, Radiation Spectrometry, Fluorescence X-Rays Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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George John, Megan Mason, Pulickel M Ajayan, Jonathan S Dordick. 2004-11-24. Lipid-based nanotubes as functional architectures with embedded fluorescence and recognition capabilities.. https://doi.org/10.1021/ja0446449

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