PubMed · 15551502
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James B Wyngaarden. 2004. Donald Sharp Fredrickson.. https://pubmed.ncbi.nlm.nih.gov/15551502/
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Previously, it has been shown for affected sib pairs that the mean test is the uniformly (in theta) most powerful test in case of a multiplicative mode of inheritance and that the mean test is equivalent to parametric linkage analysis calculated under an assumed multiplicative mode of inheritance. Here, these two results are extended to samples consisting of affected sib triplets. For affected sib quadruplets, however, it is shown that these results are no longer valid.
LigAmp is a new technique for identifying point mutations in DNA and could be a new tool for diagnosing and managing diseases.