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PubMed · 15551864

Imprinted small RNA genes.

Hervé Seitz·Hélène Royo·Shau-Ping Lin·Neil Youngson·Anne C Ferguson-Smith·Jérôme Cavaillé
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Abstract

Genomic imprinting is an epigenetic phenomenon that results in differential expression of both alleles, depending on their parent of origin. We have recently identified many imprinted small non-coding RNA genes belonging to the C/D RNA and microRNA gene families, both of which are usually known to play key roles in post-transcriptional metabolism of specific genes (e.g. C/D RNAs guide ribose methylation of target RNAs while microRNAs elicit either translational repression or RNA interference). Although the functional and evolutionary significance of this association between C/D RNA genes, microRNA genes and genomic imprinting is still highly elusive, these observations provide a framework for further analysis of the potential role of small non-coding RNAs in epigenetic control.

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AnimalsGenomic ImprintingHumansMicroRNAsRNA, Small InterferingJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Hervé Seitz, Hélène Royo, Shau-Ping Lin, Neil Youngson, Anne C Ferguson-Smith, Jérôme Cavaillé. 2004. Imprinted small RNA genes.. https://doi.org/10.1515/bc.2004.118

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