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The Paris-Sud yeast structural genomics pilot-project: from structure to function.

Sophie Quevillon-Cheruel·Dominique Liger·Nicolas Leulliot·Marc Graille·Anne Poupon·Inès Li de La Sierra-Gallay·Cong-Zhao Zhou·Bruno Collinet·Joël Janin·Herman Van Tilbeurgh
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Abstract

We present here the outlines and results from our yeast structural genomics (YSG) pilot-project. A lab-scale platform for the systematic production and structure determination is presented. In order to validate this approach, 250 non-membrane proteins of unknown structure were targeted. Strategies and final statistics are evaluated. We finally discuss the opportunity of structural genomics programs to contribute to functional biochemical annotation.

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GenomicsProtein ConformationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Sophie Quevillon-Cheruel, Dominique Liger, Nicolas Leulliot, Marc Graille, Anne Poupon, Inès Li de La Sierra-Gallay, Cong-Zhao Zhou, Bruno Collinet, Joël Janin, Herman Van Tilbeurgh. The Paris-Sud yeast structural genomics pilot-project: from structure to function.. https://doi.org/10.1016/j.biochi.2004.09.013

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