Covalent capture: a natural complement to self-assembly.

Jeffrey D Hartgerink

doi:10.1016/j.cbpa.2004.10.001

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Covalent capture: a natural complement to self-assembly.

Jeffrey D Hartgerink

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Abstract

The utility of peptide self-assembly can be extended by covalent capture of these supramolecular materials. Disulfide bond formation, native chemical ligation, olefin metathesis, radical capture and oxidative lysine cross-linking have been used recently to help stabilize and characterize a variety of self-assembled peptides. These include natural peptides, proteins and protein mimics such as alpha-helical coiled coils, amyloid-like beta-sheet fibres, portions of p53, glutathione S-transferase and elastin as well as unnatural peptide constructs such as cyclic peptide nanotubes and cylindrical micelles of peptide amphiphiles.

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Deamination Disulfides Oxidation-Reduction Peptides Protein Conformation Protein Folding Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Review

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Jeffrey D Hartgerink. 2004. Covalent capture: a natural complement to self-assembly.. https://doi.org/10.1016/j.cbpa.2004.10.001

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