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PubMed · 15560081

Molecular design of artificial ribonucleases using electrostatic interaction.

Ekaterina A Burakova·Vladimir N Silnikov
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Abstract

A number of small organic ribonucleases have been synthesized with rigid polycationic structures containing an aromatic framework with two residues of bis-quaternary salts of 1,4-diazabicyclo[2.2.2]octane (DABCO) bearing various substituents. The compounds carrying positively charged groups connected via rigid linker are expected to bend the sugar-phosphate backbone and can stimulate the intramolecular phosphoester transfer reaction.

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PiperazinesRibonucleasesStatic ElectricityJournal ArticleResearch Support, Non-U.S. Gov't

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Ekaterina A Burakova, Vladimir N Silnikov. 2004. Molecular design of artificial ribonucleases using electrostatic interaction.. https://doi.org/10.1081/ncn-200026040

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