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PubMed · 15564041

TGF-beta activation by traction?

Jorma Keski-Oja·Katri Koli·Harald von Melchner
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Abstract

Transforming growth factor (TGF)-betas are powerful cytokines that are secreted as inactive (latent) precursors into the extracellular space. To exert their pleiotropic functions, latent TGF-betas require activation. This requisite restricts TGF-beta signaling to tissues that express TGF-beta-activating proteins such as the adhesion molecule alphavbeta6 integrin. Recent work has uncovered the molecular mechanism by which alphavbeta6 integrin activates latent TGF-beta. Latent-TGF-beta-binding protein 1 has been identified as being the major component of this process, and the integrin-interacting region has been mapped to a poorly conserved sequence stretch called the hinge region.

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AnimalsAntigens, NeoplasmHumansIntegrinsIntracellular Signaling Peptides and ProteinsLatent TGF-beta Binding ProteinsModels, BiologicalProtein IsoformsStress, MechanicalTransforming Growth Factor betaJournal ArticleReview

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Jorma Keski-Oja, Katri Koli, Harald von Melchner. 2004. TGF-beta activation by traction?. https://doi.org/10.1016/j.tcb.2004.10.003

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