Inching toward reality: an improved likelihood model of sequence evolution.

J L Thorne; H Kishino; J Felsenstein

doi:10.1007/bf00163848

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Inching toward reality: an improved likelihood model of sequence evolution.

J L Thorne·H Kishino·J Felsenstein

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Abstract

Our previous evolutionary model is generalized to permit approximate treatment of multiple-base insertions and deletions as well as regional heterogeneity of substitution rates. Parameter estimation and alignment procedures that incorporate these generalizations are developed. Simulations are used to assess the accuracy of the parameter estimation procedure and an example of an inferred alignment is included.

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Animals Base Sequence Biological Evolution DNA Humans Mathematics Models, Genetic Molecular Sequence Data Sequence Alignment Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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J L Thorne, H Kishino, J Felsenstein. 1992. Inching toward reality: an improved likelihood model of sequence evolution.. https://doi.org/10.1007/bf00163848

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