[Correlation between age and average apparent diffusion coefficient in normal-appearing cerebral white matter].

Xiu-yi Zhao; Xue-lin Zhang; Jin Wang; Bin Chen; Peng Cang; Ren-min Chang

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PubMed · 15567793

[Correlation between age and average apparent diffusion coefficient in normal-appearing cerebral white matter].

Xiu-yi Zhao·Xue-lin Zhang·Jin Wang·Bin Chen·Peng Cang·Ren-min Chang

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Abstract

OBJECTIVE: To quantitatively study the effect of ages on the average apparent diffusion coefficient (ADCav) of normal-appearing white matter. METHODS: Fifty patients with normal-appearing white matter were divided into four age groups, namely 16-30 years, (n=13), 31-45 years (n=12), 46-60 years (n=14) and >60 years (n=11). All the subjects were examined with conventional and trace-weighted diffusion imaging in three orthogonal directions. The ADCav of the white matter was measured and compared between various age groups. RESULTS: In the white matter, the ADCav of all the patients was (0.71+/-0.08) x 10(-3) mm2/s; the ADCav of the white matter in the first to fourth age groups were (0.69+/-0.06) x 10(-3) mm2/s, (0.71+/-0.07) x 10(-3) mm2/s, (0.71+/-0.09) x 10(-3) mm2/s, and (0.73+/-0.10) x 10(-3) mm2/s respectively. ADCav of patients between 16-30 years was significantly different from that of patients over 60 years of age (P=0.014). Patients older than 60 years had an ADCav of the white matter significantly higher than the value of (0.70+/-0.07) x 10(-3) mm2)/s in the total patients younger than 60 years (P=0.026). CONCLUSION: Water diffusibility shows a slight increase in human white matter with aging, possibly due to mild ultrastructural changes associated with aging.

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Adolescent Adult Age Factors Aged Aging Brain Diffusion Magnetic Resonance Imaging Female Humans Image Processing, Computer-Assisted Male Middle Aged Reference Values Thalamus English Abstract Journal Article

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Xiu-yi Zhao, Xue-lin Zhang, Jin Wang, Bin Chen, Peng Cang, Ren-min Chang. 2004. [Correlation between age and average apparent diffusion coefficient in normal-appearing cerebral white matter].. https://pubmed.ncbi.nlm.nih.gov/15567793/

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