Concomitant information in bioassay and semi-parametric estimation.

Peter T Kim; Christine H Lee

doi:10.1002/sim.1973

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Concomitant information in bioassay and semi-parametric estimation.

Peter T Kim·Christine H Lee

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Abstract

This paper presents a flexible modern approach to handling concomitant information for estimating the relative potency parameter in quantitative bioassays. This is accomplished in a semi-parametric framework where the concomitant variable is included non-parametrically. Estimation is then performed using smoothing splines where the point and interval estimators of the relative potency parameter exhibits desirable asymptotic properties.

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Animals Biological Assay Computer Simulation Data Interpretation, Statistical Drug Evaluation Models, Statistical Comparative Study Journal Article Research Support, Non-U.S. Gov't

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Peter T Kim, Christine H Lee. 2005-05-15. Concomitant information in bioassay and semi-parametric estimation.. https://doi.org/10.1002/sim.1973

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