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Complement component C5 is not involved in scrapie pathogenesis.

Neil A Mabbott·Moira E Bruce
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Abstract

During transmissible spongiform encephalopathy (TSE) infections the accumulation of abnormal prion protein within the brain is often accompanied by severe neurodegeneration. Studies have implicated complement, including the membrane attack complex (MAC, C5b-C9), in inducing pathology in some neurodegenerative diseases. Recent studies show the MAC is localized on neurons in the brains of TSE patients implicating complement-mediated cell lysis in TSE neuropathology. To determine the role of the MAC in TSEs, we compared scrapie pathogenesis in C5-deficient and C5-sufficient mice. C5-deficient mice developed clinical scrapie with incubation periods similar to C5-sufficient mice. Furthermore, the severity of the neuropathology was not significantly different between C5-deficient and C5-sufficient mice. These data show that C5, and the MAC, are not involved in TSE pathogenesis.

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AnimalsBrainComplement C5MiceScrapieJournal ArticleResearch Support, Non-U.S. Gov't

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Neil A Mabbott, Moira E Bruce. 2004. Complement component C5 is not involved in scrapie pathogenesis.. https://doi.org/10.1016/j.imbio.2004.06.003

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