CD23 expression in mediastinal large B-cell lymphomas.

M Calaminici; K Piper; A M Lee; A J Norton

doi:10.1111/j.1365-2559.2004.01969.x

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CD23 expression in mediastinal large B-cell lymphomas.

M Calaminici·K Piper·A M Lee·A J Norton

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Abstract

AIMS: Mediastinal large B-cell lymphoma (MLBCL) is a subtype of diffuse large B-cell lymphoma (DLBCL) in the WHO classification with peculiar features, such as female prevalence, young patient age and bulky presentation. It shows a B-cell phenotype with variable expression of surface immunoglobulin, negative CD21 and CD10 and positive CD30 in a large number of cases. An origin from activated thymic B cells has been suggested in several studies. A subpopulation of large, dendritic cells (asteroid cells) strongly expressing CD23 has been identified amongst thymic B cells and these could represent the normal cellular counterpart for this type of primary mediastinal large cell lymphoma. METHODS AND RESULTS: To explore this possibility, we immunostained 24 cases of primary mediastinal lymphomas and 100 cases of non-mediastinal, nodal and extranodal, DLBCLs for CD23 in routinely processed paraffin-embedded tissues. CONCLUSIONS: Our results show that a vast majority (70%) of mediastinal lymphomas strongly express CD23 whilst the same antigen is expressed in only 15% of non-mediastinal nodal DLBCLs and 9% of non-mediastinal extranodal DLBCLs. These results support the hypothesis that most cases of MLBCL arise from activated dendritic thymic B cells. We also suggest that CD23 should be included in the panel of antibodies currently used to characterize this subtype of DLBCL.

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M Calaminici, K Piper, A M Lee, A J Norton. 2004. CD23 expression in mediastinal large B-cell lymphomas.. https://doi.org/10.1111/j.1365-2559.2004.01969.x

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Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.

Association between plasma homocysteine levels and P-wave dispersion in pediatric patients with hyperhomocysteinemia.

Characteristics of post-exercise responders versus non-responders following aerobic or isometric exercise in physically inactive adults of African and South Asian descent with high-normal blood pressure or grade I hypertension.