PubMed Health⌕ Search

PubMed · 15577018

[Genes affecting bone quality].

Abstract

Many genes have been shown to affect bone mass. However, because there have been only a few methods to evaluate bone quality, little is known about the genes that determine bone quality. Recently, several genes including collagen and vitamin D receptor genes have been shown to affect bone quality. With the establishment of methodology to determine bone quality more easily, we will learn much about the genes that affect bone quality in the near future.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Seiji Fukumoto. 2004. [Genes affecting bone quality].. https://pubmed.ncbi.nlm.nih.gov/15577018/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

A hypothetical mechanism of bone remodeling and modeling under electromagnetic loads.

A hypothetical regulation mechanism for bone modeling and remodeling under electromagnetic field is proposed. In this hypothesis, the bone modeling and remodeling mechanism is described as follows: the circular loads that we bear during ordinary daily activities generate micro-damage in cortical bone and these micro-cracks are removed by osteoclasts. Then growth factors, which are in latent forms in osteocytes, are activated by osteoclasts and released into bone fluid. These growth factors stimulate osteoblasts to refill the cavities. An electromagnetic field can stimulate the multiplication of growth factors and accelerate the bone remodeling process indirectly. It can be seen that many features reported in adaptive bone modeling and remodeling are explained by the proposed hypothesis. Further, a computational model is established based on the hypothesis, which can simulate the bone modeling and remodeling process under multi-field loads.

Bone Remodeling↗

Collagen fiber orientation near a fractured dental implant after a 5-year loading period: case report.

PURPOSE: Fracture of an implant is one of the possible complications of dental implants. It is a quite rare event but of high clinical relevance. Nevertheless, it represents an important opportunity for evaluating the peri-implant bone-tissue response to implant overloading in human beings. The aim of the present study was a scanning electron microscopy evaluation of a screw-shaped implant retrieved because of fracture and a birefringence analysis of the tissue near the fractured implant. MATERIALS AND METHODS: There was 1 fractured screw-shaped implant retrieved from a patient with a trephine bur, and it was processed for histology. The specimen was analyzed under both scanning electron microscopy and circularly polarized light microscopy. RESULTS: The scanning electron microscopy fractography analysis showed the typical signs of a fatigue-fracture, with large plastic deformations on the implant. The fracture seemed to start from the internal coil of the implant. Under circularly polarized light microscopy investigation, a bone-implant contact percentage of 81.6% +/- 1.5% (mean +/- standard deviation) was found. The amount of the transverse collagen fibers was of 68.3%, and the amount of the longitudinal collagen fibers was of 31.7%. The difference was statistically significant for z = 2.247 (P = 0.025). CONCLUSION: The fracture of the implant was most probably correlated to a fatigue of the material mainly associated to a lesion of the internal coil. The high level of bone-implant contact percentage was correlated to a predominant transverse collagen fiber orientation of the collagen fibers in the peri-implant bone.

Bone Remodeling↗

Posterior subluxation and dislocation of the shoulder in obstetric brachial plexus palsy.

We describe the results of surgical treatment in a prospective study of 183 consecutive cases of subluxation (101) and dislocation (82) of the shoulder secondary to obstetric brachial plexus palsy between 1995 and 2000. Neurological recovery was rated 'good' or 'useful' in all children, whose lesions fell into groups 1, 2 or 3 of the Narakas classification. The mean age at operation was 47 months (3 to 204). The mean follow-up was 40 months (24 to 124). The mean gain in function was 3.6 levels (9.4 to 13) using the Mallet score and 2 (2.1 to 4.1) on the Gilbert score. The mean active global range of shoulder movement was increased by 73 degrees ; the mean range of active lateral rotation by 58 degrees and that of supination of the forearm by 51 degrees . Active medial rotation was decreased by a mean of 10 degrees . There were 20 failures. The functional outcome is related to the severity of the neurological lesion, the duration of the dislocation and onset of deformity.

Bone Remodeling↗