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PubMed · 15577079

[Relationship between gene transfer and cartilage tissue engineering].

Hiroaki Seto·Sakae Tanaka·Hisashi Kurosawa
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Abstract

Injury to the articular cartilage occurs under various pathological conditions such as trauma, inflammation and aging and is followed by osteoarthritic changes of the affected joints. Recently, some studies have revealed that enough chondrogenic proliferation was required using some factors such as TGF-beta and BMPs. We, also, have reported that synovial tissues include multipotent mesenchymal stem cells, which can differentiate into chondrocytes. These results suggest that not only are synovial cells a good therapeutic target of inflammatory joint diseases, but also can be utilized for tissue engineering of cartilage.

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AdenoviridaeAnimalsBone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsCartilage, ArticularCell DifferentiationChondrocytesGene Transfer TechniquesGenetic VectorsHumansMesenchymal Stem CellsMultipotent Stem CellsOsteochondritisProtein Serine-Threonine KinasesReceptors, Growth FactorRegenerationRegenerative MedicineSynovial MembraneTissue EngineeringTransforming Growth Factor betaJournal ArticleReview

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Hiroaki Seto, Sakae Tanaka, Hisashi Kurosawa. 2004. [Relationship between gene transfer and cartilage tissue engineering].. https://pubmed.ncbi.nlm.nih.gov/15577079/

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