Primary vaginal adenosarcoma with sarcomatous overgrowth.

Masafumi Toyoshima; Jun-ichi Akahira; Takuya Moriya; Seiichirou Hayakawa; Nobuo Yaegashi

doi:10.1016/j.ygyno.2004.08.004

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Primary vaginal adenosarcoma with sarcomatous overgrowth.

Masafumi Toyoshima·Jun-ichi Akahira·Takuya Moriya·Seiichirou Hayakawa·Nobuo Yaegashi

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Abstract

BACKGROUND: Primary vaginal adenosarcomas are extremely rare, and typical adenosarcomas are of low malignancy. However, aggressive forms with sarcomatous overgrowth have been reported, those appear to have a poor prognosis. CASE: A 52-year-old woman who had undergone prior surgery for uterine leiomyoma and an ovarian cyst (total abdominal hysterectomy and left salpingo-oophorectomy) presented 10 years later with a rapidly enlarging tumor arising from the vaginal cuff. Repetitive biopsy samples revealed a mixture of benign epithelial gland and malignant stromal components with periglandular stromal hypercellularity and sarcomatous overgrowth. A histological diagnosis of mullerian adenocarcinoma was made. The patient died from recurrent disease 9 months after surgery. CONCLUSION: Regardless of primary focus, adenosarcoma with sarcomatous overgrowth is associated with postoperative recurrence and a fatal outcome.

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Adenosarcoma Antineoplastic Combined Chemotherapy Protocols Fatal Outcome Female Humans Hysterectomy Leiomyoma Middle Aged Neoplasm Recurrence, Local Ovariectomy Uterine Neoplasms Vaginal Neoplasms Case Reports Journal Article

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Masafumi Toyoshima, Jun-ichi Akahira, Takuya Moriya, Seiichirou Hayakawa, Nobuo Yaegashi. 2004. Primary vaginal adenosarcoma with sarcomatous overgrowth.. https://doi.org/10.1016/j.ygyno.2004.08.004

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