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PubMed · 15582225

Cell size relations for sonolysis.

Morton W Miller
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Abstract

The occurrence of cell lysis following exposure to ultrasound (US) has been well documented; the specifics of the mechanistic process(es) involved have proven to be difficult to characterize. There appear to be two major mechanisms of US-induced cell lysis in vitro, acoustic cavitation and bubble transport. Both involve shear forces. Earlier research showed that the size of oil droplets was a crucial factor in their rupture by shear forces; the greater the size the greater the rupture per unit shear force. Here we find further support (Miller et al. 2000, 2001a, 2003a; Miller and Battaglia 2003; Abramwocz et al. 2003) that, under a number of experimental US conditions causing hemolysis in vitro, cell volume (i.e., size) is an apparently critical factor.

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AnimalsCattleCell SizeErythrocyte IndicesHemolysisHumansMiceRabbitsTime FactorsUltrasonicsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Morton W Miller. 2004. Cell size relations for sonolysis.. https://doi.org/10.1016/j.ultrasmedbio.2004.07.005

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