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PubMed · 15582539

Steroid epimers studied by different mass spectrometric methods.

Marianna Mák·Erzsébet Francsics-Czinege·Zoltán Tuba
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Abstract

The combined use of different mass spectrometric ionization methods and MS/MS techniques provide the possibility to differentiate between stereoisomers or epimers. In this paper the mass spectral decomposition of 11alpha- and 11beta-substituted estrans was studied. Distinctive stereochemical effects have been observed in their fast atom bombardment product ion spectra. In the electron ionisation (EI) mode, the 5alpha- and 5beta-hydroxylated compounds showed significant differences in the abundance of water elimination. Mass spectrometry has proved to be an effective tool when stereoisomer steroids are compared.

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EstranesMass SpectrometryMolecular StructureStereoisomerismJournal Article

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Marianna Mák, Erzsébet Francsics-Czinege, Zoltán Tuba. 2004. Steroid epimers studied by different mass spectrometric methods.. https://doi.org/10.1016/j.steroids.2004.09.013

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