Structural relationships of actin-binding proteins.

J Vandekerckhove; K Vancompernolle

doi:10.1016/0955-0674(92)90056-i

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Structural relationships of actin-binding proteins.

J Vandekerckhove·K Vancompernolle

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Abstract

The sequences of a large number of actin-binding proteins have been compared. These findings, together with the results of protein-chemical analysis, peptide synthesis and site-directed and deletion mutagenesis, have led to the assignment of actin-binding sites. Within these segments, small actin-binding motifs have been delineated. Most actin-binding proteins interact with actin subdomain-1 but our analyses reveal neither primary nor secondary structure homology among these proteins, suggesting that actin binding does not follow simple structural principles.

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Actins Amino Acid Sequence Animals Binding Sites Microfilament Proteins Molecular Sequence Data Sequence Homology, Nucleic Acid Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Review

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J Vandekerckhove, K Vancompernolle. 1992. Structural relationships of actin-binding proteins.. https://doi.org/10.1016/0955-0674(92)90056-i

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