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NXY-059: a neuroprotective agent in acute stroke.

C X Wang·A Shuaib
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Abstract

Free radicals play an important role in secondary processes in ischaemic brain injury. Disodium 4-[(tert-butylimino) methyl] benzene-1,3-disulphonate N-oxide (NXY-059) is a nitrone-based free radical trapping agent. Findings from animal stroke models showed that NXY-059 is a potent neuroprotective agent that has a large window of therapeutic opportunity and long-lasting effects. Therefore, NXY-059 may be used as a monotherapy agent for treatment of acute stroke. NXY-059 may also be used as an adjunct agent to thrombolytic therapy, as it can reduce tissue plasminogen activator-induced haemorrhage in ischaemic stroke.

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AnimalsBenzenesulfonatesFree RadicalsHumansMaleNitrogen OxidesRabbitsRatsStrokeTreatment OutcomeJournal ArticleResearch Support, Non-U.S. Gov'tReview

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C X Wang, A Shuaib. 2004. NXY-059: a neuroprotective agent in acute stroke.. https://doi.org/10.1111/j.1368-5031.2004.00245.x

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