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Finding the maximum safe dose level for heteroscedastic data.

Ajit C Tamhane·Brent R Logan
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Abstract

In this article we extend to the heteroscedastic setting the multiple stepwise test procedures proposed in Tamhane et al. [Tamhane. A. C., Dunnett, C. W., Green, J. W., Wetherington, J. F. (2001). Multiple test procedures for identifying a safe dose. J. Am. Statist. Assoc. 96:835-843] for finding the maximum safe dose. Toxicological data are often heteroscedastic; therefore, the extensions given herein should be highly useful in practice. Simulations are performed to study the Type I familywise error rate and power properties of the procedures. A real data example is given to illustrate the procedures.

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AlgorithmsAnimalsComputer SimulationData Interpretation, StatisticalDose-Response Relationship, DrugDrug-Related Side Effects and Adverse ReactionsMonte Carlo MethodPharmaceutical PreparationsRatsJournal ArticleResearch Support, Non-U.S. Gov't

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Ajit C Tamhane, Brent R Logan. 2004. Finding the maximum safe dose level for heteroscedastic data.. https://doi.org/10.1081/bip-200035413

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