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Protein interactions and fluctuations in a proteomic network using an elastic network model.

Melik C Demirel·Ozlem Keskin
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Abstract

A set of protein conformations are analyzed by normal mode analysis. An elastic network model is used to obtain fluctuation and cooperativity of residues with low amplitude fluctuations across different species. Slow modes that are associated with the function of proteins have common features among different protein structures. We show that the degree of flexibility of the protein is important for proteins to interact with other proteins and as the species gets more complex its proteins become more flexible. In the complex organism, higher cooperativity arises due to protein structure and connectivity.

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AnimalsComputational BiologyCrystallography, X-RayHumansModels, MolecularProtein BindingProtein ConformationProtein FoldingProtein Structure, TertiaryProteinsProteomicsThermodynamicsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Melik C Demirel, Ozlem Keskin. 2005. Protein interactions and fluctuations in a proteomic network using an elastic network model.. https://doi.org/10.1080/07391102.2005.10507010

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