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Kinetics of cytomegalovirus load decrease in solid-organ transplant recipients after preemptive therapy with valganciclovir.

F M Mattes·E G Hainsworth·A F Hassan-Walker·A K Burroughs·P Sweny·P D Griffiths·V C Emery
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Abstract

The availability of valganciclovir (VGCV) has significantly simplified the treatment of human cytomegalovirus (HCMV) infection after solid-organ transplantation. We show that there was no difference in the kinetics of the decrease in HCMV load after preemptive therapy with VGCV in 22 solid-organ transplant recipients (T1/2=2.16 days), compared with that in 23 patients treated with intravenous ganciclovir (GCV) (T(1/2) = 1.73 days; P=.63). Preemptive therapy with VGCV provides control of HCMV replication that is comparable to that achieved with preemptive intravenous therapy with GCV.

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Administration, OralAdultAntiviral AgentsCytomegalovirusCytomegalovirus InfectionsFemaleGanciclovirHumansInjections, IntravenousKineticsMaleMiddle AgedRetrospective StudiesTransplantsValganciclovirViral LoadVirus ReplicationComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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F M Mattes, E G Hainsworth, A F Hassan-Walker, A K Burroughs, P Sweny, P D Griffiths, V C Emery. 2004-11-29. Kinetics of cytomegalovirus load decrease in solid-organ transplant recipients after preemptive therapy with valganciclovir.. https://doi.org/10.1086/425905

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