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PubMed · 15595747

Polymer cushions functionalized with lipid molecules.

Dong-Chan Lee·Bong-Jun Chang·Luping Yu·Shelli L Frey·Ka Yee C Lee·Sirisha Patchipulusu·Connie Hall
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Abstract

This Letter reports a novel approach to the fabrication of a biomimicking surface by modification of an end-functionalizable smooth polymer cushion constructed via chemoselective ligation with a phospholipid-like molecule containing oxyamine groups. The mobility of a phospholipid bilayer formed by vesicle fusion on the phospholipid-like molecule terminated polymer film was characterized by fluorescence recovery after bleaching. Platelet adhesion, as one measure of biocompatibility of the film was also studied and compared to other surfaces such as polyethylene or poly(dimethylsiloxane). The results show that the end-functionalized smooth polymer cushion has potential as a biocompatible platform to reconstitute membrane proteins.

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Fluorescence Recovery After PhotobleachingLipid BilayersLipidsMicroscopy, Atomic ForceMolecular StructurePlatelet AdhesivenessPolymersJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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Dong-Chan Lee, Bong-Jun Chang, Luping Yu, Shelli L Frey, Ka Yee C Lee, Sirisha Patchipulusu, Connie Hall. 2004-12-21. Polymer cushions functionalized with lipid molecules.. https://doi.org/10.1021/la0474722

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