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PubMed · 15609003

Dendritic cell-mediated T cell polarization.

Esther C de Jong·Hermelijn H Smits·Martien L Kapsenberg
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Abstract

Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4(+) T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T cells are controlled by regulatory T cells. The optimal balance in the development of the different types of effector and regulatory Th cells is orchestrated by dendritic cells (DC). This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response.

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AnimalsAntigens, CDB7-1 AntigenB7-2 AntigenDendritic CellsHumansInterferon Type IInterleukin-10Interleukin-12Interleukin-18Interleukin-4Membrane GlycoproteinsModels, ImmunologicalOX40 LigandSignal TransductionT-Lymphocytes, Helper-InducerTh1 CellsTh2 CellsJournal ArticleReview

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Esther C de Jong, Hermelijn H Smits, Martien L Kapsenberg. 2004-10-14. Dendritic cell-mediated T cell polarization.. https://doi.org/10.1007/s00281-004-0167-1

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