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PubMed · 15611637

Nucleolus in the spotlight.

D Hernandez-Verdun
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Abstract

The recent contributions on chromatid segregation at the metaphase/anaphase transition demonstrate two distinct pathways in budding yeast. While segregation of most of the genome is a direct consequence of cohesin cleavage by separase, rDNA segregation requires a novel pathway involving Cdc14 phosphatase activation. This activation induces targeting of condensin to rDNA which in association with Aurora B kinase modulates rDNA compaction during anaphase. The resolution of rDNA sequences occurs after this step.

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AnaphaseAurora KinasesCell Cycle ProteinsCell DivisionCell NucleolusChromatidsChromosomal Proteins, Non-HistoneDNA, RibosomalEnzyme ActivationFungal ProteinsNuclear ProteinsProtein Serine-Threonine KinasesProtein Tyrosine PhosphatasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription, GeneticCohesinsJournal ArticleReview

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D Hernandez-Verdun. 2005-01-10. Nucleolus in the spotlight.. https://doi.org/10.4161/cc.4.1.1355

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